Exploring the Complexity of Biological Neurons: How Dendrites Function as Deep Neural Networks

Dendrites – Why biological neurons are deep neural networks
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Artem is my name. I am a student and researcher in computational neuroscience. This video will show us why individual neurons function like deep convolutional networks with their insane information processing abilities, as well as the physiological mechanisms that explain such computational complexity.

Patreon: https://www.patreon.com/artemkirsanov.
Twitter: https://twitter.com/ArtemKRSV

00:00 Introduction.
01:42 — Perceptrons.
03:43 — Electric excitability and Action Potential
07:12 — Cable Theory: Passive Dendrites
09:03 — Active dendritic properties.
12:10 — Human neurons as XOR gates
19:11 — Single neurons as deep neural networks.
22:32 — Brilliant.
23:57 — Recap & Outro

REFERENCES (in no particular order):
1. Bicknell, B. A., Bicknell, B. A. A. Neuron (2021) doi:10.1016/j.neuron.2021.09.044.
2. Matthew Larkum Are dendrites useful conceptually? Neuroscience (2022) doi:10.1016/j.neuroscience.2022.03.008.
3. Polsky A., Mel B. W. & Schiller J. Computational Subunits in Thin Dendrites of Pyramidal Cells. Nature Neuroscience 7621-627 (2004).
4. Tran-Van-Minh, A. et al. Contribution of supralinear and sublinear dendritic Integration to Neuronal Computations Frontiers in Cellular Neuroscience, 9, 67-67 (2005).
5. Gidon, A. et al. Dendritic actions potentials and computation of human layer 2/3 cortex neurons. Science 367, (2020), 83-87.
6. London, M. & Hausser, M. DENDRITIC COMPUTATION. Annu. Rev. Neurosci. 28503-532 (2005).
7. Branco, T., Clark, B. A. & Hausser M. Dendritic discrimination of temporal input sequences in cortical neurons. Science 329,1671-1675 (2010).
8. Stuart, G. J. & Spruston N. Dendritic Integration: 60 Years of Progress. Nat Neurosci 18, 1713-1721 (2015).
9. Smith, S. L.; Smith, I. T.; Branco, T. and Hausser M. Dendritic Spikes Enhance Stimulus Selectivity in Cortical Neurons in Vivo. Nature 503115-12 (2013).
10. Beniaguev, D., Segev, I. & London, M. Single cortical neurons as deep artificial neural networks. Neuron 109, (2021).
11. Michalikova M., Remme M. W. H. Schmitz D. Schreiber S. & Kempter R. Spikelets: generating mechanisms and distinguishing properties in pyramidal neuronal cells. Reviews in the Neurosciences 3101-119 (2019).
12. Larkum, M. E., Wu, J., Duverdin, S. A. & Gidon, A. The Guide to Dendritic Spokes of the Mammalian Cortex In Vitro & In Vivo Neuroscience 489, 15-33 (2022).

Icons by https://biorender.com.
Brain 3D models were modeled with Blender software using publicly available BrainGlobe atlases (https://brainglobe.info/atlas-api)